ABSTRACT
A series of N-benzyl-N-[1-piperidin- l-yl cyclohexylmethyl] benzamides 5a-i has been synthesized and evaluated for their analgesic, anticonvulsant and antihistaminic activities. The highest peripheral analgesic potency was achieved with compound 5f [20mg/kg] in respect with acetylsalicylic acid [200mg/kg]. Compound 5g exhibited the highest anticonvulsant property among the series and 10 fold as active as diphenylhydantoin soduim [DPH.Na] used as reference drug since it showed 100% lrotection at a dose level of 5 mg/kg while the reference drug gave 100% protection at 50 mg/kg. Moreover, the highest inhibitory activity on plasma histamine level was displayed with compound 5d [62%,3Omg/kg] compared with chlorpheniramine maleate [50%,0.3 mg/kg]